In addition to optic neuropathy, one patient was diagnosed with central nervous system (CNS) inflammatory syndrome, one with acute disseminated encephalomyelitis (ADEM), three with giant cell arteritis (GCA), three with neuromyelitis optica spectrum disorder (NMOSD), and five with myelin-oligodendrocyte-glycoprotein (MOG) antibody-associated disease. The gene discussed is OMG; the disease is optic nerve disorder.