Diagnosed with SLE 10 years earlier. Fundus exam: normal OU without optic disc swelling. VF: paracentral VF contraction OU. Aquaporin-4 IgG antibody titer was positive at 1:1000. OCT: mild paracentral optic nerve thickening OS. VEP: mild to moderate prechiasmatic optic pathway dysfunction OS with secondary axonal loss. MRI: abnormal signal intensity and enhancement within the intraocular and intraorbital optic nerve OS. Optic neuritis diagnosed OS. This evidence concerns the gene AQP4 and systemic lupus erythematosus.