The depletion of NK cells strongly suppresses the potentiation of immune checkpoint blockage action by interleukin (IL)-18, which regulates innate immunity, enhances the anti-tumour effect of immune checkpoint blockage through the induction of characteristic NK cells, which accumulate in the peritoneal cavity during early treatment prior to CD8+ T cells, and expresses CXCL1, whose depletion decreases the recruitment of CD103+CXCR1+ cDCs to the peritoneum [272,273,274]. The gene discussed is CD8A; the disease is neoplasm.