The interaction between T cell-expressed integrin alpha L (LFA1) and ICAM-1 on the vascular endothelium initiates T cell infiltration into tumours that are suppressed by vascular endothelial growth factor A (VEGF-A), which is produced by cancer cells, further releasing new cancer antigens and continuing the cancer immune cycle [250,251,252]. The gene discussed is VEGFA; the disease is cancer.