At Tpost, in the LuT patients, we found a lower percentage of IFNγ+IL2+TNFα+ CD8+ T-cells (0.03 [0.00–0.10] and 0.10 [0.05–0.13], respectively, p = 0.0171), IFNγ+IL2+TNFα-CD8+ T-cells (0.00 [0.00–0.00] and 0.10 [0.05–0.10], respectively, p = 0.0003), IFNγ+IL2-TNFα- CD8+ T-cells (0.00 [0.00–0.00] and 0.14 [0.07–0.51], respectively, p = 0.00031) and IFNγ-IL2-TNFα+ CD8+ T-cells compared with HD (0.09 [0.01–0.24] and 0.44 [0.09–0.81], respectively, p = 0.0423). Here, IFNG is linked to Huntington disease.