To enable early detection of COVID-19 patients, particularly in emergency rooms, we contribute to the identification of a practical and precise diagnostic biomarkers of COVID-19 disease by prospectively evaluating the levels of five cytokines, prostaglandin E2 (PGE2), thromboxane A2 (TXA2), TXA2, NF-κB p50, NF-κB p65, and NRP-1. The gene discussed is NFKB1; the disease is COVID-19.