RGS12 and periodontitis: In addition, Yuan et al. have found that the deletion of RGS12 inhibits osteoclastogenesis, as well as the expression of inflammatory cytokines and macrophages migration in response to the stimulation of lipopolysaccharide (LPS), which demonstrates that the restraint of RGS12 in macrophages is a potential therapeutic target for preventing bone loss in periodontitis treatment [20].