ROR1 and mantle cell lymphoma: In the present study, the expression of ROR1 in MCL cells was characterized and the apoptotic effects of a novel ROR1 inhibitor, KAN0441571C, were evaluated in in vitro and ex vivo preclinical models as well as in combination with therapeutics with other MOAs of clinical relevance (ibrutinib, idelalisib, bendamustine, everolimus, and venetoclax) that are currently used for the treatment of patients with MCL [28] or have shown promising results in clinical trials.