CD47 and neoplasm: In the work of Kamerkar et al. [67], Du J. et al. [68], and Cheng L. et al. [69], we can find that by introducing a CD47-overexpressing eukaryotic expression vector into EV-derived cells, CD47 surface functionalization enables EVs to effectively escape the phagocytosis of the mononuclear phagocyte system (MPS), and thus increases the distribution in tumor tissues and reduces liver toxicity.