Strikingly, the AuPEI nanocomposites significantly decreased the percentage of tumor-infiltrating immature macrophages (CD11b+ MHCIIhi Ly6Chi) from 48.8% down to 8.42% (AuPEI-2.5) and 11.1% (AuPEI-5) (Figure 3B,C). The gene discussed is ITGAM; the disease is neoplasm.