MUC5AC and neoplasm: Other cells such as fibroblasts contribute to the intricate tumor microenvironment (TME) by supporting not only tumor cell growth and immune response suppression through different soluble factors [4,5,6] but also by secreting extracellular matrix components, e.g., collagens and mucin, that affect tumor stiffness and interstitial pressure, a documented characteristic of desmoplastic tumors [4,7].