KCNT1 and developmental and epileptic encephalopathy: Furthermore, genetic variants in KCNT1 have emerged as an important cause of epilepsy with a wide phenotypic spectrum, including autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) in children and adults and an early infantile developmental and epileptic encephalopathy (EIDEE) in infants and children [6].