Furthermore, in agreement with the established tumor-intrinsic role of PD-L1 in promoting EMT in TNBC cells [33], which is independent of its role as an immune checkpoint, both the siPD-L1 positive control and the extracted siPD-L1 strongly reduced the protein levels of the EMT transcription factor Snail (Figure 5A). The gene discussed is CD274; the disease is neoplasm.