A comparative analysis of the present results and data from our previous studies on triple-gene therapy for stroke in rats with MCO, using the intrathecal injection of human genetically engineered UCB-MC expressing recombinant molecules VEGF, GDNF, and NCAM in the acute phase [10] and for preventive treatment [11], revealed similar effects of gene therapy on the cortical remodelling in rats and mini-pigs. This evidence concerns the gene GDNF and Stroke.