The role of TNF-α in AD pathogenesis has been well studied [6], and our previous work highlighted the protective effects of the brain-penetrant TfRMAb-TNFR in 6-month-old APP/PS1 male mice compared to etanercept, a biologic TNF-α inhibitor with limited brain uptake [17,26]. The gene discussed is TNFRSF1A; the disease is Alzheimer disease.