SESN2 and neoplasm: Although there are a variety of debated mechanisms for how hypoxia affects the tumor landscape, it is well established that hypoxia inducible factor 1 and 2 (HIF-1/2), hypoxia-regulated transcription factors, modulate the expression of hypoxia-inducible genes including, but not limited to, the growth factor regulating genes, tumor survival genes, etc. [18].