For example, in chemotherapy-responsive tumors, the use of high doses of chemotherapeutic agents may be effective against cancer cells (facilitating the release of tumor antigens), induce the selection of immune subpopulations with antitumor properties (Th1.17, CD8+ CD161+ T cells), but limit the spread of MDR1-negative Treg cells. This evidence concerns the gene ABCB1 and cancer.