NOTCH1 and neoplasm: It should be noted, however, that in mice with a completely blocked Notch1 pathway (Lyz2Cre Notch1 f/f, Lyz2Cre Notch1 f/+), a TAM polarization to the M2 phenotype, a decrease in secretion of Th1 cytokines, and an increase in production of Th2 cytokines were observed, which was associated with high tumor growth (OS) [183].