ONECUT2 and neoplasm: The results of Western blot showed that the downregulation of OC-2 evidently induced the up-regulation of the active cleaved fragment of Caspase-3 in tumor tissues, suggesting that OC-2 knockdown mediated by targeted or nontargeted CL/pshOC-2 lipoplexes actually promoted tumor apoptosis in vivo (Figure 6F,G), which was in line with the results of H&E staining and TUNEL assay of tumor sections (Figure 7).