CALR and breast cancer: Experiments on BC tumor models showed that the self-assembled photosensitive nanocomposites CH3-R9-RGD@ce6/siP3H4 in a molar ratio of 30/1 inhibited P3H4 (mRNA and protein) expression, promoted CRT protein exposure, suppressed BC tumor cell proliferation, reduced 1O2 production, and promoted cell apoptosis in vitro and suppressed BC tumor growth in vivo.