The summarized result of the biological evaluation showed that 20a possessed a high level of MKN-45 gastric cancer cell aggregation activity, which was a sign of PPAR-induced cancer differentiation; moreover, 20a was metabolically unstable during activation so Yamamoto et al. identified a metabolically weak area of the work and effectively discovered a 3-fluoro dibenzoxapine derivative (20b) with better metabolic stability. The gene discussed is PPARA; the disease is cancer.