Furthermore, various transmembrane receptors such as CD44 [15,16,17,18,19,20], folate (FA) [21,22], mannose receptors [23,24,25,26] and CD98 [27,28], are overexpressed not only on the inflamed colitis tissue but also on activated macrophage surfaces, providing potential binding sites for active-targeting systems. The gene discussed is CD44; the disease is colitis.