Thus, in this study, we explored the anti-cancer properties of Omeg@Silica microparticles using NSCLC cells lines which originate from different geographical districts of the lung, in particular adenocarcinoma (A549) and mucoepidermoid (NCI-H292) lung cancer cell lines, by evaluating cell migration, as well as the expression/release of IL-8, NF-κB, and miRNA-21. The gene discussed is CXCL8; the disease is non-small cell lung carcinoma.