In conclusion, after studying in vitro the effect of whole fish oil encapsulated in mesoporous silica formulated in aqueous ethanol on adenocarcinoma (A549) and mucoepidermoid (NCI-H292) lung cancer cell lines, we discovered that a formulation comprised of submicron mesoporous silica particles functionalized with whole fish oil extracted with limonene only (Omeg@Silica) dispersed in aqueous ethanol (FOS) reduces IL-8 release, affecting cell migration and cancer progression in lung cancer cells. This evidence concerns the gene CXCL8 and lung carcinoma.