CYP1B1 and Hypertension: One such derivative is the methylated analogue 2,3′,4,5′-tetramethoxystilbene (TMS), shown to be 1000 times more potent in inhibiting CYP1B1 associated with hypertension, reducing NADPH oxidase activity, ROS generation, and subsequently rescuing endothelial dysfunction in spontaneously hypertensive rats than RV [5,7,8].