CXCL12 and neoplasm: Miao and Shen separately designed nanoparticles that co-load chemokine C-X-C motif ligand 12 (CXCL12) traps with Interleukin-10 (IL-10) or PD-L1 traps to synergistically change the immunosuppressive microenvironment of PDAC and modify the immunosuppressive TIME to allow the host’s immune system to kill the tumor cells [87,88].