Figure 5C,E are of particular interest. Two different patterns were observed. (i) In most areas, all cells were labeled with the two aptamers. This result highlighted, using bioimaging, the already known co-expression and potential crosstalk between EGFR and integrin α5β1 in GBM [32]. (ii) However, in some areas, such as the one shown with the gray arrow in Figure 5C,E, one could note a lower fluorescence intensity obtained with the E07 aptamer than in the side areas, which highlighted that dual apta-labeling was not identical among cells within the tumor. Here, EGFR is linked to neoplasm.