The GluN1 subunit, encoded by GRIN1, is typically involved in loss-of-function mutations contributing to structural changes resulting in a wide range of epilepsies of variable semiology (spasms, tonic and atonic seizures, hypermotor seizures, focal dyscognitive seizures, febrile seizures, generalized seizures, status epilepticus, myoclonic seizures, etc.)[74]. This evidence concerns the gene GRIN1 and early-infantile DEE.