Immune response by immunologically abnormal Th2 cells is induced by high antibody production, and plays a role in activating B cell proliferation and class conversion, thereby causing cytokines interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP) to increase in keratinocytes of AD patients [4,5,6]. This evidence concerns the gene IL25 and Alzheimer disease.