Many of the aforementioned positive effects of polyphenols on HDL particles were confirmed in clinical settings, like increased HDL and antioxidant functions in subjects with T2DM or improved cholesterol efflux, inhibited CETP, and increased HDL levels in dyslipidemic subjects by anthocyanins supplementation [552,553,554], increased PON1 activity by catechins-supplementation in haemodialysis patients [555], increased HDL cholesterol by flavanones in orange juice [556] and others [536]. This evidence concerns the gene CETP and type 2 diabetes mellitus.