Although oral Lp-PLA2 inhibitor darapladib showed promising anti-inflammatory and plaque-reducing properties in a pre-clinical swine model of atherosclerosis [531] and subsequent clinical trial, it prevented the expansion of necrotic core that is the determinant for plaque vulnerability, in large clinical trials STABILITY and SOLID TIMI 52, darapladib failed to improve the incidence of CVD events in patients [532,533]. The gene discussed is PLA2G7; the disease is atherosclerosis.