Resveratrol inhibited LDL and HDL oxidation, enhanced apoA-I mediated cholesterol efflux by up-regulating ABCA1 and reduced cholesterol influx in macrophages [543], ameliorated atherosclerosis induced by high-fat diet (HFD), or LPS in apoE−/− mice [544]; and prevented the development of atherosclerotic lesion, lowered the Lp-PLA2 levels in HFD-fed rabbits [545]. This evidence concerns the gene PLA2G7 and atherosclerosis.