In contrast, the HD + BTi group did not develop insulin resistance (7759 ± 477 AUC), since its area under the curve in the insulin sensitivity test was similar to that of the ND + water group (7784 ± 312 AUC), as demonstrated in Figure 1B. There was no difference between the glycemic curves in response to insulin injection in the ND + water group (7784 ± 312 AUC) compared to the ND + BTi group (7129 ± 426 AUC) (p > 0.05). This evidence concerns the gene INS and Insulin resistance.