CHM and Pruritus: However, heterogeneity of VAS scores (pruritus severity) was not significant after <8 weeks of treatment with CHM (I2 = 49%, p = 0.12) or with UCG (I2 = 0%, p = 0.88); similarly, pruritus scores based on the Dirk R. Kuypers itch-intensity scale was also not significant (I2 = 0%, p = 0.74).