Our meta-analysis suggests that CHM significantly reduces various pruritus scores in UP patients (VAS, Duo, and Dirk R. Kuypers itch-intensity scores), improves sleep quality (PSQI) and quality of life (QOL), renal function (eGFR, BUN, and SCr), and alleviates inflammation (CRP, TNF-α, β2-MG, and IL-6). The gene discussed is TNF; the disease is Pruritus.