KLRK1 and glioblastoma: In this respect, a study on the human malignant glioma cell lines LNT- 229 and LN-308 NMRI nude mice revealed that TSA causes upregulation of natural killer group-2 member-D (NKG2D) ligands and immunogenicity in GBM cells and the retardation of tumor growth of GBM xenografts (in vivo) [27].