To explore the potential effects of TSA against pancreatic cancer (PC) cells, Emonds et al. [30] demonstrated that the cytotoxic effect of TSA in PC cells is associated with the increase of acetyl-H3, p21Waf1, phospho-p38 and Bax levels, and the decrease of phospho- ERK 1/2 and phospho-AKT. The gene discussed is AKT1; the disease is pachyonychia congenita.