The anticancer activity of TSA against ovarian carcinoma cells could be mediated by the upregulation of Krüppel-like factor 4 (klf4) which plays a tumor-suppressor role in the SKOV3 cell line upon TSA treatment [140], and the apoptotic effect induced by TSA was enhanced by the inhibition of Akt [136]. This evidence concerns the gene KLF4 and ovarian carcinoma.