TWIST1 and cancer: To explain the effects of TSA on epithelial-mesenchymal transition (EMT) in human cancer cells, Han et al. [149] reported that TSA treatment induces mesenchymal-like morphological modifications in MCF-7 breast cancer cells and BGC-823 human gastric cancer, increases the expression rate of the mesenchymal markers vimentin and twist, and suppresses cancer cell colony formation in both cell lines which led to the dysregulation of the critical signaling molecule involved in EMT named of β-catenin.