It was noted that the treatment with GE and TSA inhibited cell growth, downregulated the DNMT1 gene expression after 48 and 72 h of treatment, and DNMT3a gene expression only after 72 h, and promoted apoptosis in all tested groups of Human HCC HepG2 cells [47]. Importantly, TSA may play a role in preventing hepatocellular carcinoma by inhibiting apoptosis and reducing the expression of DNMT1. This evidence concerns the gene DNMT3A and hepatocellular carcinoma.