Our study introduced new information that CAN decreased Ang II and boosted Ang (1–7) in the lungs of CIS-treated rats, findings supporting the studies showing its ability to modulate ACE2-Ang (1–7)-mas axis in the heart of murine models of cardiotoxicity [36] and pressure overload-induced cardiac remodeling [37]. This evidence concerns the gene ACE2 and in situ carcinoma.