LPO, assessed as thiobarbituric acid reactive substances (TBARS; Figure 2A), and nitric oxide (NO) (Figure 2B) levels, myeloperoxidase (MPO) activity (Figure 2C), GSH (Figure 2D), and SOD (Figure 2E) were determined to assess the effect of CAN on oxidative stress induced by CIS. This evidence concerns the gene SOD1 and Crouzon syndrome-acanthosis nigricans syndrome.