ACHE and Alzheimer disease: Although the effectiveness of ACh inhibition in the treatment of AD has been debated in recent years [4], after the discovery of AChE’s role in Aβ aggregation when was demonstrated that the AChE peripheral anionic site interacts with Aβ forming a stable AChE-Aβ complex which is more toxic than Aβ peptide aggregates [5,6], the search on AChE inhibitors was boosted again [7].