In an in vitro study by Clodfedler et al. (2004), the trinuclear cation [Cr3O(O2CCH2CH3)6(H2O)3]+ was found to imitate the chromodulin’s ability to increase the tyrosine kinase enzyme activity of the insulin receptor, improve insulin sensitivity, and decrease total cholesterol and LDL cholesterol levels, as well as decrease triacylglycerols concentration in healthy and type 2 diabetic rat models [50,51]. This evidence concerns the gene INS and type 2 diabetes mellitus.