MAPT and Alzheimer disease: A marked enhancement of memory and cognitive functions and a significant reduction of the levels of inflammatory markers and the AD pathogenesis hallmarks, β-amyloid and tau proteins, were observed together with histopathological signs of neuroprotective efficacy in dentate Gyrus sub-regions of mice treated with artichoke extract and to a greater extent with chitosan-coated artichoke-loaded solid lipid nanoparticles.