Ahmet et al. [77] reported that pioglitazone analogue significantly regulates Streptozotocin-Induced T2D through stimulating local angiotensin-converting enzyme 2/angiotensin 1-7 axis with the aid of PI3K/AKT/mTOR Signaling pathway in the hepatic tissues, thereby regulating glycogen deposition and enhancing lipolysis. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.