Even though many previous studies demonstrated the beneficial effect of PPAR ligands in the treatment of T2D patients with cardiovascular complications and endothelial damage, to date, few studies have examined the beneficial effect of PPARƳ ligand agents on miR-126-5p and Pi3k/AKT/PDK1/mTOR expression in T2D-induced vascular damage. This evidence concerns the gene PPARA and type 2 diabetes mellitus.