Our in vitro and in vivo experiments further confirmed the activation of astrocyte ferroptosis in AD (Figure 9), but how these two hub genes (FTH1 and SAT1) affect astrocyte ferroptosis requires further experimental verification.In the current study, we demonstrated that astrocytes underwent ferroptosis in the entorhinal cortex of AD, and the cognitive and behavioral functions of 5xFAD mice also deteriorated compared with WT mice. Here, SAT1 is linked to Alzheimer disease.