Compared with controls, 42 mRNAs (e.g., LINGO1, NEAT1, and GFAP) were significantly upregulated, while 52 mRNAs (e.g., LSAMP-AS1, SLC6A1-AS1, and NRXN1) downregulated in AD (Figure 4F). The gene discussed is NRXN1; the disease is Alzheimer disease.