IL1B and ischemic stroke: In addition, astrocytes, microglia, neurons, and endothelial cells release cytokines that secrete pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), IL-6, and IL-18, accountable for neuronal and glial cell death following ischemic stroke [22,23].