In another work, it was shown that congenital errors in TLR3 and IRF7-dependent type I IFN immunity underlie critical COVID-19, demonstrating the essential role of both the TLR-3 double-stranded RNA sensor and intrinsic immunity to type I IFNs in controlling SARS-CoV-2 infections in the lungs. Here, TLR3 is linked to COVID-19.