A further aspect investigated was the change in the prevalence of these Abs at the diagnosis of the disease and at different years since diagnosis, and whether these changes follow a trend referable to an important β-cellular autoimmunity marker, such as ZnT8, which plays an important role in the progression of the disease and which has been identified as one of the main biomarkers for type 1 diabetes. The gene discussed is SLC30A8; the disease is type 1 diabetes mellitus.