Besides the GNAS c.393C>T polymorphism, somatic missense mutations such as R201H, R201L, R201s, and R201C in the exon 8 of the GNAS gene and mutations in the exon 9 such as Q227R and Q227L were identified to have a clinical significance in several tumor entities [8,16,17,18]. Here, GNAS is linked to neoplasm.