The serum levels of cytokines and molecules involved in the regulation and co-stimulation of the immune response, such as IL-10, TGF-ß, and sCTLA-4, were assessed by ELISA in healthy donors (HD IgG−), non-comorbid seronegative and seropositive subjects (IgG− and IgG+, respectively), and comorbid seropositive subjects (DM IgG+ and HTN IgG+). The gene discussed is IL10; the disease is hypertensive disorder.