In the MR of inflammatory factors on NAFLD, we first obtained the following number of SNPs that that was significant in terms of genome-wide threshold (p < 5 × 10−8, r2 < 0.001, and kb < 10,000): IL-1β (23), IL-6 (23), IL-16 (3), IL-17 (13), and IL-18 (8). Here, IL16 is linked to metabolic dysfunction-associated steatotic liver disease.