In another study, both peptides were also able to attenuate atherosclerosis development in apolipoprotein E-deficient mice by reducing the expression of the proinflammatory cytokines IL-6 and IL-1b and the NF-kB-related genes CD40, LCK, PIK3CG, IL1B, and MAP2K7 [68]. The gene discussed is IL1B; the disease is atherosclerosis.