CCK and gallbladder disorder: Otherwise, we should also consider the great improvement in CD diagnosis and management in the last two decades, which has significantly reduced the diagnostic delay (even in atypical and/or mild forms) and allowed a prompt implementation of GFD, at least in developed countries [51,52,53]; as a consequence, CD-related gallbladder disease may manifest much less frequently than in the case of a longer clinical history without diagnosis and dietary therapy, which can reverse CCK alterations and gallbladder dysmotility, as previously highlighted.