NTN-1 exerts chemoattractive or chemorepulsive functions depending on its receptors, including neogenin-1 (NEO-1), deleted in colorectal carcinomas (DCC), A2B receptor (A2BAR), uncoordinated-5 homolog family members (UNC5A, UNC5B, UNC5C, and UNC5D), CD146, and integrin subunits [8]. Here, NEO1 is linked to colorectal carcinoma.