The upregulation of NEO1 in adipocytes after the treatment with NTN-1 together with the lack of changes in the expression of UNC5B and DCC suggest that NTN-1 mainly signals through NEO-1 in VAT during obesity, being reinforced by the positive correlation found between the expression levels of NTN1 and NEO1 in the VAT. The gene discussed is NTN1; the disease is obesity disorder.