TNF and Alzheimer disease: Zou et al. reported that the expression levels of proinflammatory cytokines, including IL-6, IL-1β, and TNF-α, increased significantly in Aβ25-35-induced AD mice, and these factors were markedly attenuated by oral gavage of walnut (Juglans sigilata Dode) protein hydrolysate at doses of 200, 400, or 800 mg/kg in distilled water once daily for 5 weeks [24].