CYP17A1 and polycystic ovary syndrome: Treatment with combined KH + metformin (2.85 ± 0.12), KH + clomiphene (2.89 ± 0.08), clomiphene (3.03 ± 0.07), KH only (3.15 ± 0.11), and metformin (3.22 ± 0.08) significantly downregulated the Cyp17a1 mRNA expression (p < 0.05) compared to the untreated PCOS group (4.93 ± 0.13).