As shown in Figure 8, after 5 weeks of the administration of NFL-L, NFL-H, WEHI01-L, and WEHI01-H, the mRNA levels of Cebpα, Pparγ, Fas, and Acc in adipose tissue were significantly decreased regarding the HFD group (p < 0.001), which indicates that FLLS-WEHI01 and NFLLS ameliorated the HFD-induced obesity by inhibiting adipogenesis and lipogenesis in obese rats. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.