FAS and obesity due to melanocortin 4 receptor deficiency: Figure 9 shows a schematic image of fermented lotus leaf treatment for inhibiting obesity in HFD-induced obese rat.The oral administration of FLLS-WEHI01 significantly decreased body weight, epididymal fat mass, TC and TG in liver, LDL-C levels, and fasting blood glucose, in addition to improving insulin resistance in HFD-induced obese rats, which might have occurred through the modulation of adipogenic transcription factors, such as Pparγ, Cebpα, Acc, and Fas.