Figure 9 shows a schematic image of fermented lotus leaf treatment for inhibiting obesity in HFD-induced obese rat.The oral administration of FLLS-WEHI01 significantly decreased body weight, epididymal fat mass, TC and TG in liver, LDL-C levels, and fasting blood glucose, in addition to improving insulin resistance in HFD-induced obese rats, which might have occurred through the modulation of adipogenic transcription factors, such as Pparγ, Cebpα, Acc, and Fas. This evidence concerns the gene CEBPA and obesity due to melanocortin 4 receptor deficiency.