In our analysis, EGFR showed great impact in the PPI network-liver cirrhosis with a Degree of 149, Betweenness of 0.0245, and Closeness of 0.4498, which curcumin strongly interacts with and blocks its function with a low binding affinity energy of −8.9 kcal/mol. Here, EGFR is linked to cirrhosis of liver.