In this study, the proteoglycans in the cancer pathway were significantly identified with a set of genes that included AKT1, CTNNB1, EGFR, FN1, SRC, STAT3, TNF, and TP53, which was the highest pathway in biological pathways analysis that was influenced by curcumin in liver cirrhosis. The gene discussed is AKT1; the disease is cirrhosis of liver.