Nonetheless, BRD9 expression and pRPA32 were interrelated (Figure 4F), and up to a 6-fold increase in pH2AX and pRPA32 expression in colon cancer cells treated with iBRD9 or natural polyphenols (Supplementary Figure S1) suggests that DNA damage/repair pathways are worthy of further investigation. The gene discussed is BRD9; the disease is malignant colon neoplasm.