FOS and hypertensive disorder: Accordingly, the present study aimed to explore the dysregulated tissue levels of SCFAs and expression of FFARs in the hypothalamic paraventricular nucleus (PVN), a major brain region engaged in the regulation of sympathetic activity [38], of offspring to maternal HFD exposure, as well as their rectification that underpins the beneficial effects of prebiotic (fructooligosaccharides, FOS), probiotic (Lactobacillus gasseri, L. gasseri), synbiotic (FOS+L. gasseri) and postbiotic (butyrate) on programmed hypertension.