FFAR2 and Hypertension: Nonetheless, we found no significant change in GPR43 mRNA in the PVN of HFD offspring at the age of 3, 6, or 12 weeks, or its distribution in the PVN of adult offspring, implying that its role in the pathogenesis of hypertension programmed by maternal diet might not be as impactful as the other two SCFA-sensing receptors in the PVN.