Compared to scramble shRNA (Lv-sc-RNA) controls, programmed hypertension, increases in plasma NE levels, and LF component of SBP signals in adult HFD offspring were significantly attenuated by microinjection of Lv-GPR41-shRNA or Lv-olfr78-shRNA into the PVN (Figure 6C). This evidence concerns the gene FFAR3 and hypertensive disorder.