Additionally, peritoneal dialysis, a therapeutic method for removing metabolites and wastes from the blood, can significantly lower the plasma Aβ levels in patients and APP/PS1 mice, attenuate AD pathology (such as Tau hyperphosphorylation, glial activation, neuroinflammation, neuronal loss, and synaptic dysfunction), and increase Aβ phagocytosis in microglia, as well as rescue cognitive impairment in the animals [44]. This evidence concerns the gene PSEN1 and Alzheimer disease.